Effect of carbetocin administration during the mid-period of parturition on farrowing duration, newborn piglet characteristics, colostrum yield and milk yield in hyperprolific sows

Abstract

Control of the farrowing process is crucial to reduce the risk of post-parturient disorders in sows and newborn piglet mortality. Carbetocin is a long-acting oxytocin-like compound that has been introduced to domestic animal obstetrics. The aims of the present study were to evaluate the effects of carbetocin administration during the mid-period of parturition on farrowing duration as well as colostrum and milk production and its side effects on neonatal piglet characteristics in hyperprolific sows. The study included 89 Landrace x Yorkshire crossbred sows and 1534 piglets. Sows were randomly distributed into two groups: CONTROL (n = 46), where sows were allowed to farrow naturally, and TREATMENT (n = 43), where sows were administered 0.5 μg/kg carbetocin intramuscularly after the birth of the 7th piglet. In each litter, the piglets were classified into two groups according to birth order: 1–7 and ≥8. The colostrum yield of sows and the colostrum intake of each individual piglet were calculated. Litter weight gain of the piglets from 3 to 5 days of lactation was used to estimate milk yield. Farrowing duration tended to be reduced from 338.4 ± 35.2 min in the CONTROL group to 255.3 ± 36.4 min in the TREATMENT group (P = 0.105). However, the colostrum yield in the TREATMENT group was lower than that in the CONTROL group (3828 ± 149 and 3041 ± 158 g, respectively, P < 0.001). Nevertheless, milk yield during 3–5 days of lactation in the TREATMENT group did not differ significantly compared to that in the CONTROL group (7.53 ± 0.01 and 7.54 ± 0.01 kg/day, respectively, P = 0.643). The incidence of stillbirths in the TREATMENT group was not significantly different from that in the CONTROL group (8.3 and 7.4%, respectively, P = 0.944). However, the incidence of piglets born with umbilical cord rupture in the TREATMENT group with birth order ≥8 was higher than that in the CONTROL group in the same birth order (16.6 and 5.7%, P < 0.001). Across groups, colostrum intake of piglets born with birth order ≥8 was lower than that of piglets born in the birth orders 1–7 (187.4 ± 8.7 and 241.5 ± 9.0 g, P < 0.001). Interestingly, the colostrum intake of piglets with birth orders 1–7 in the TREATMENT group was also lower than that of piglets with the same birth order in the CONTROL group (214.9 ± 12.9 and 268.1 ± 12.5 g, respectively, P = 0.003). Colostrum intake was lowest in the piglets with birth order ≥8 in the TREATMENT group (159.6 ± 12.3, P < 0.001). Carbetocin administration after the birth of the 7th piglet reduced the birth interval of piglets but increased the incidence of piglets born with umbilical rupture and reduced colostrum intake. Therefore, colostrum supplementation and care of the newborn piglets immediately after birth are strongly recommended after carbetocin administration.