Abstract
Carbenoxolone significantly decreased the glucose uptake and the incorporation of glucose into triglycerides and CO 2 in rat epididymal fat pads. The effect produced by insulin on these metabolic pathways was reduced when adipose tissue was incubated with insulin in the presence of carbenoxolone (10 −3 M). On the other hand the drug (10 −3 M) produced a decrease in cyclic AMP concentration in adipose tissue similar to that produced by insulin (100 ng/ml).
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