Abstract
ABSTRACTWe planned to investigate the protective effect of soy isoflavone (SIF) genistein (GEN), and daidzein (DAI), and their mixed solution against carbaryl-induced toxicity in PC12 cells. PC12 cells were exposed to carbaryl, pretreated, co-treatment, or posttreatment with three different SIF solutions for indicated times. Exposure to SIF resulted a better survival and cell morphology which were subjected to carbaryl toxicity. Treatment with SIF was also found to reduce malondialdehyde content, superoxide dismutase inhibitory rate, reactive oxygen species generation, acetylcholine levels in medium, and maintain the integrity of mitochondrial membrane potential. It was also found to increase GSH level. In conclusion, SIF can effectively mitigate adverse effects induced by carbaryl. GEN and DAI have a combined effect that is greater than the effect obtained with each isoflavone alone, although they have different effects against carbaryl-induced damage. SIF enhances metabolism of choline and plays a role as both antioxidant and neuroprotectant.
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