Abstract

Carbachol markedly depressed the activity of phosphoenolpyruvate carboxykinase in the liver of rats. On a 60% casein-diet, its effect was counteracted by atropine. In contrast, carbachol significantly increased the activity of liver glucokinase in fasted rats. These findings suggest that the parasympathetic nervous system is involved in regulation of carbohydrate metabolism, depressing gluconeogenesis, and activating glycolysis in the liver.

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