Abstract
The effect of carbachol on the absorptions of caffeine, aminopyrine and salicylic acid in the rat small intestine was studied, using an in situ recirculating perfusion method. Carbachol, either added to the perfusate or injected intravenously, remarkably reduced drug absorption. Upon the addition of carbachol, the perfusate volume of intestine decreased markedly and there was a positive correlation between the perfusate volume and the drug absorption rate. No physicochemical interaction, as determined by measurement of the partition coefficient between isoamyl acetate or benzene and phosphate buffer (pH 7.0), was noted between the drugs and carbachol in solution. Our results suggest that the carbachol-induced decrease in drug absorption is due to a reduction in the perfusate volume in the intestine upon recirculating perfusion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
