Abstract
The specific mammalian mutagen bioassay system involving polygenic reproductive fitness was tested by using two generations of the offspring of captan treated male DBA 2J mice. The fungicide captan ( N-(trichloromethylthio)tetrahydrophthalimide) was given at doses of 50 or 100 mg/kg/day for 5 days. The known mutagen triethylenemelamine (TEM) was used as the positive control compound (0.1 mg/kg dose). TEM produced decreases in overall productivity (as measured by the fertility index) and decreased survival from birth to day 4, and from day 5 to weaning at 21 days. Captan treated animals also showed a decrease in fertility index, but neither dose of captan provoked the severity of decreases seen after TEM treatment. The decrease in average weaning weight seen in the first litter of the second generation after the high dose of captan suggests that the effects of captan on certain characteristics may be nearly as serious as those of TEM.
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