Abstract
Objective To determine whether calcium supplementation could improve the bone mineral density(BMD) in healthy children. Methods Search strategies (calcium supplementation, bone density, randomized controlled trials) was applied to the following databases: Pubmed, Medline, Embase, CINAHL, AMED, MANTIS, ISI Web of Science, CENTRAL. The researches that had randomized placebo controlled trials of calcium supplementation in healthy children lasted at least three months and had BMD outcomes measured after at least six months follow-up from 1966-2017 were seletced. Data were extracted from the text, two reviewers independently exracted data and analysis. Results Twenty-one eligible studies of 3072 healthy children were included. There was no effect on BMD on femoral neck[SMD=0.09, 95%CI(-0.06, 0.21)] or lumbar spine[SMD=0.07, 95%CI(-0.03, 0.22)] when treated with calcium supplementation (P>0.05). Calcium supplementation had persistent effect on upper limb BMD after stopping supplementation [SMD=0.14, 95%CI(0.01, 0.28), P 0.05]. Female children were sensitive to the calcium compared with male children. There was no correlation of bone mineral content between pubertal stage, baseline calcium intake or ethnicity. Conclusion Healthy children who treated on calcium supplementation is impossible to reduce the risk of bone fracture. Key words: Calcium; Minors; Bone density
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