Abstract
Induction of hemoglobin synthesis of Friend leukemia cells is inhibited by changing the ratio between internal and external Ca 2+ concentrations. The concentration ratio can be successfully manipulated by the addition of the growth medium of (1) Ca 2+ channel blocker D600 (90 n M-4 × 10 2 n M), (2) Ca 2+ ionophore A23187 (1 × 10 2–2 × 10 2 n M), and (3) EGTA at molar concentrations comparable to the Ca 2+ concentration of the medium formulation (3 × 10 2 μ M). The observations suggest that a specific ratio between intra- and extracellular Ca 2+ is required for erythroid differentiation to proceed.
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