Abstract
Spasticity is a stiff muscle condition because the muscles receive impulses continuously. Calcium ions play a role in the ability of nerves to stimulate muscle contraction. This study aimed to analyze the effect of calcium consumption on the changes of spasticity and the relation of calcium levels in the blood and muscle to the spasticity. The experimental study was conducted on 42 male Sprague-Dawley rats aged 12 - 14 weeks. The 15-d intervention was conducted on six groups of spastic rats by administering 20 g of feed containing 50 mg, 100 mg, and 200 mg of calcium, it also received 100 mg, 200 mg, and 300 mg of calcium lactate supplementation. The experimental rats were induced with 80 mg/kg BW of Erythrocin B through the tail vein to make them spastic. This study showed a tendency of increased spasticity along with the increased dose of calcium given to the subjects. There were significant differences (p = 0.007) in changes in spasticity between groups. The significant differences (p = 0.02) in changes in blood calcium levels. The Spearman’s correlations test on the changes in blood calcium levels and changes in spasticity showed a positive coefficient correlation (r = 0.097) with a p-value of 0.54. An increase in blood calcium levels and a large decrease in spasticity were found in the group receiving 100 mg calcium intake in 20 g of feed. The calcium levels in muscles had a significant correlation with spasticity (p = 0.038, r = 0.810). The calcium levels in the muscle had a strong correlation with blood calcium levels (p = 0.041, r = 0.748). The biggest decrease in spasticity occurred after 100 mg of calcium were given to the rats for 15 days, and it was considered as an optimal dose. The calcium levels in the muscles had a strong correlation with blood calcium levels and the spasticity of the spastic rats.
Highlights
Spasticity is a stiff muscle condition because the muscles receive impulses continuously
This study showed a tendency of increased spasticity along with the increased dose of calcium given to the subjects
Optimal dose of daily calcium intake in spastic rats obtained at 100 mg is half of the standard dose contained in the daily diet
Summary
Spasticity is a stiff muscle condition because the muscles receive impulses continuously. The nerves that stimulated muscle cannot control the impulse that goes in so that the muscles continuously suffered hypertonic and caused the weakness of muscle. The condition affects to the muscle activity and ability to walk [1]. Spasticity occurred most on cerebral palsy (CP) for almost 70% - 80% and can caused physical disability. CP is a group of symptoms movement and posture that cause problems related to physical access that is experienced individuals in the brain development time. One of a movement disorder in CP is the stiffness in muscle because of the disruption from the central nerve that attack the upper motor neuron or usually known as spastic condition [2]
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