Abstract
Fivefold administration of L-type Ca2+ channel blocker verapamil in a dose of 1.5 mg/kg to newborn rats increased the parameters of DNA-synthetic activity in the myocardium: labeling index and intensity increased 1.24-fold on average. Body weight decreased with simultaneous increase in the absolute and relative heart weight. Morphometric parameters of the nucleus and nucleoli were practically unaffected. Our findings suggest that the Ca2+ channel blocker verapamil administered at the early postnatal stages can modulate morphogenesis of the heart
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