Abstract
This study aimed to observe and analyze the effect of calcitriol combined with sevelamercarbonate on serum parathyroid hormone in patients with chronic renal failure. This study included 180 patients who had been treated for chronic renal failure in our hospital were enrolled as research objects. The patients were randomly divided into two groups: a research group and a control group, each containing 90 cases. The research group was treated with calcitriol combined with sevelamer carbonate, and the control group was treated with calcitriol alone. The therapeutic effects of the two groups were observed and analyzed by SPSS 21. Comparing the levels of blood indexes (Ca, Cr, P, ALP, iPTH, TC, TG, LDL-C, HDL-C) of the two groups showed no significant difference between the two groups, P <0.05. Our results have the effect of different treatment regimens, the improvement effect of various blood indicators in the research group was significantly better than the control group, p<0.05. We concluded that the combined therapy of calcitriol and sevelamer carbonate in chronic renal failure patients can significantly improve the therapeutic effect, and at the same time actively improve the serum parathyroid hormone level, which is a treatment model that can be popularized and applied.
Highlights
Chronic renal failure (CRF) is a clinical syndrome characterized by chronic progressive renal parenchymal damage caused by various causes, obvious renal atrophy, inability to maintain basic functions, metabolic product retention, imbalance of water, electrolyte, acid and base balance, and systemic involvement (1,2)
The research group was treated with calcitriol combined with sevelamer carbonate, and the control group was treated with calcitriol alone
Chronic renal failure (CRF) is a kidney damaging disease caused by many factors, which can be accompanied by multi-system damage
Summary
Chronic renal failure (CRF) is a clinical syndrome characterized by chronic progressive renal parenchymal damage caused by various causes, obvious renal atrophy, inability to maintain basic functions, metabolic product retention, imbalance of water, electrolyte, acid and base balance, and systemic involvement (1,2). The main causes of renal failure in patients include primary glomerulonephritis, chronic pyelonephritis, hypertensive arteriolosclerosis, diabetic nephropathy, secondary glomerulonephritis, tubular interstitial lesions, hereditary kidney diseases, and long-term use of antipyretic analgesics and exposure to heavy metals (3). Chronic renal failure in patients presents with uremia, uremia is not an independent disease, but it is a symptom of kidney damage and progressive deterioration. When renal diseases develop to the end stage and renal failure, the renal function is up to 10% ~ 15% of normal renal function, which caused a series of clinical symptoms The treatment principle is to reduce blood phosphorus (P), adjust the reasonable application of blood calcium (Ca), 1, 25-dihydroxyvitamin D3 [1, 25(OH) 2 D3], and surgical treatment (7–9)
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