Abstract
The augmentations of hepatic and renal blood flow, induced by parathyroid hormone (PTH) were assessed on anaesthetized dogs. Extracts of porcine and salmon calcitonin as well as the equivalent synthetic calcitonin preparations inhibited the PTH—induced hepatic vasodilation. Salmon calcitonin extract seemed to inhibit the PTH—induced renal vasodilation, but synthetic salmon calcitonin had no such effect. The reason for this discrepancy is not clear. Synthetic human calcitonin up to a dosage of 100 μg/kg did not antagonize die vasodilator action of PTH at all. Calcitonin decreased the maximal augmentation of arterial hepatic flow that could be induced by PTH. This suggests a non—competitive antagonism. (Endocrinology 91: 828, 1972
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