Abstract
The effect of two doses of synthetic salmon calcitonin (SCT) on meal-stimulated gastric acid secretion (measured by intragastric titration) and gastrin response was measured in 5 normal subjects. SCT, in a dose of 1.0 Medical Research Council U per kg per hr, inhibited meal-stimulated acid secretion 48%, while 0.25 Medical Research Council U per kg per hr of SCT suppressed acid secretion 9%. Neither dose of SCT had any effect on the serum gastrin response to the meal. Thus, SCT suppresses meal-stimulated acid secretion by a mechanism other than inhibition of serum immunoreactive gastrin response.
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