Abstract
The effect of calcitonin gene-related peptide (CGRP) on the cyclic nucleotide level in isolated mouse diaphragm was investigated. CGRP at concentrations of up to 1 μM caused dose-dependent increases in cyclic AMP levels but had no effect on cyclic GMP levels. At 1 μM, CGRP increased cyclic AMP levels by about 2.7-fold. Moreover, in the presence of phosphodiesterase inhibitor (Ro 20–1724), CGRP still caused even greater dose-dependent increases in cyclic AMP levels. Even in the presence of propranolol, a beta-adrenergic antagonist, CGRP stimulated increased cyclic AMP CGRP was observed in mouse diaphrag increases intracellular cyclic AMP levels adrenergic receptor.
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