Abstract
This study was to analyze the diagnostic value of coronary computed tomography angiography (CCTA) and fractional flow reserve (FFR) based on computer-aided diagnosis (CAD) system for coronary lesions and the possible impact of calcification. 80 patients who underwent CCTA and FFR examination in hospital were selected as the subjects. The FFR value of 0.8 was used as the dividing line and divided into the ischemic group (FFR ≤ 0.8) and nonischemic group (FFR > 0.8). The basic data and imaging characteristics of patients were analyzed. The maximum diameter stenosis rate (MDS %), maximum area stenosis rate (MAS %), and napkin ring sign (NRS) in the ischemic group were significantly lower than those in the nonischemic group (P < 0.05). Remodeling index (RI) and eccentric index (EI) compared with the nonischemic group had no significant difference (P > 0.05). The total plaque volume (TPV), total plaque burden (TPB), calcified plaque volume (CPV), lipid plaque volume (LPV), and lipid plaque burden (LPB) in the ischemic group were significantly different from those in the non-ischemic group (P < 0.05). MAS % had the largest area under curve (AUC) for the diagnosis of coronary myocardial ischemia (0.74), followed by MDS % (0.69) and LPV (0.68). CT-FFR had high diagnostic sensitivity, specificity, accuracy, truncation value, and AUC area data for patients in the ischemic group and nonischemic group. The diagnostic sensitivity, specificity, accuracy, cutoff value, and AUC area data of CT-FFR were higher in the ischemic group (89.93%, 92.07%, 95.84%, 60.51%, 0.932) and nonischemic group (93.75%, 90.88%, 96.24%, 58.22%, 0.944), but there were no significant differences between the two groups (P > 0.05). In summary, CT-FFR based on CAD system has high accuracy in evaluating myocardial ischemia caused by coronary artery stenosis, and within a certain range of calcification scores, calcification does not affect the diagnostic accuracy of CT-FFR.
Highlights
Cardiovascular disease, known as circulatory system disease, is a series of diseases involving the circulatory system
80 patients with confirmed coronary artery disease by imaging examination, aged 35-80 years, who were admitted to hospital for coronary computed tomography angiography (CCTA) examination and fractional flow reserve (FFR) examination from May 2, 2019 to June 5, 2021, were selected as the study subjects. 49 males and 31 females were divided into 40 cases of the coronary ischemia group (FFR ≤ 0:8) and 40 cases of the noncoronary ischemia group (FFR > 0:8)
As a noninvasive imaging technology commonly used in clinic, CCTA has been proved to have high accuracy in diagnosing coronary artery diameter stenosis of cardiovascular diseases
Summary
Cardiovascular disease, known as circulatory system disease, is a series of diseases involving the circulatory system. It has become the primary noncommunicable disease threatening global public health. Coronary heart disease is a heart disease caused by atherosclerotic lesions in the coronary artery, resulting in stenosis or obstruction of the vascular cavity, myocardial ischemia, hypoxia, or necrosis [3]. It has been proposed that the pathophysiological basis of acute coronary syndrome is the rupture of “vulnerable” single criminal plaque, which promotes the formation of acute thrombosis in situ and leads to the occurrence of acute coronary events [4, 5]. The fight against cardiovascular disease has become a common challenge for all mankind regardless of region, race, and country
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