Abstract
Xenopus laevis cells were treated with mitomycin C and subsequently treated with caffeine during either the S- or G2-phase of the cell cycle. The frequency of induced chromatid exchanges was especially increased by caffeine posttreatment during the S-phase. This increase took place at the expense of the frequency of isochromatid breaks, which was reduced, both when the caffeine posttreatment was given during the S- and G2-phase.
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Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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