Effect of caffeine gel and caffeine gel associated with iontophoresis in women gynoidlipodystrophy: A pilot randomized trial

Alana Roberta Forti Quessada,Thainá Bessa Alves,Rodrigo Antonio Carvalho Andraus,André Lucino Pinto,Ovídia Ignez Pires,Karina Couto Furlanetto,Audrey Alesandra Stinghen Garcia Lonni

doi:10.33448/rsd-v10i4.13813

Alana Roberta Forti Quessada, Thainá Bessa Alves + Show 5 more

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https://doi.org/10.33448/rsd-v10i4.13813

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Abstract

Caffeine has been widely used to treat gynoid lipodystrophy (GLD). Despite caffeine has been considered as a promise treatment, there is a lack of scientific evidences regarding its effect on GLD when associated with iontophoresis or others equipment. We aimed to evaluate the effects of a caffeine gel alone and associated with iontophoresis in GLD treatment. In a single-blind randomized clinical trial, women with mild/moderate GLD in the buttocks were randomized to topical caffeine gel group (CG; n=10); caffeine gel plus iontophoresis group (CIG; n=11) or iontophoresis group (IG; n=10). The groups were treated with 10 sessions, two times/week, 20 min/session. The subjects were evaluated pre and post treatment by photonumeric GLD severity scale, ultrasound image, thermography and quality of life questionnaire with a blind evaluator. There were statistical reduction in subcutaneous tissue thickness (P≤0.046) as well as in subcutaneous tissue plus dermis thickness (P≤0.044) in buttocks both in CG and CIG. GLD reduction was similar between CG and CIG, and these reductions were more pronounced than in IG (P<0.0001). Furthermore, quality of life improved in all groups (P<0.017). We concluded that caffeine alone and associated with iontophoresis were effective for decreasing the subcutaneous fat layer in women with GLD.

Highlights

Gynoid lipodystrophy (GLD), know as cellulite, is a localized metabolic disorder wich increases the subcutaneous tissue and affects between 80-90% of the post-pubertal women population (Janda & Tomikowska, 2014)
The sample was composed by women with age 25 ± 5 years, body mass index (BMI) ± 4 kg/m2, Cellulite Severity Scale of 6 ± 2.5 points and CELLUQOL of ± 6 points
The use of caffeine gel alone and caffeine gel associated with iontophoresis is efficient on reduction of subcutaneous tissue thickness in woman with gynoid lipodystrophy (GLD) imafter 10 sessions when assessed by ultrasound

Summary

Introduction

Gynoid lipodystrophy (GLD), know as cellulite, is a localized metabolic disorder wich increases the subcutaneous tissue and affects between 80-90% of the post-pubertal women population (Janda & Tomikowska, 2014). Increased subcutaneous thickness, which is characterized by adipocytes hypertrophy, commonly cause changes in the local circulation resulting in hypoxia and tissue homeostasis alterations, leading to a local fibrotic response and arising collagen strands (Emanuele, 2013). Several treatments have been carried out to reduce the subcutaneous fat layer (Atamoros et al, 2018), such as the use of cosmetics containing active substances of natural origin Methylxanthines, such as caffeine, are common examples that stimulate lipolysis and reduce the lipogenesis of adipocytes and act in the skin microcirculation

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