Abstract
A comparative study of the power and coherence of the ultraslow phasic processes (USPPs) of the brain in the frequency range 0.05–0.5 Hz and the EEG (1.5–50 Hz) at rest with the eyes opened or closed before and after the administration of caffeine and phenazepam, a benzodiazepine tranquilizer, was performed. Caffeine and phenazepam caused similarly directed changes in the EEG pattern. The differences between the effects of these drugs were expressed in a different topography of changes in the EEG pattern. Different locations of such changes are supposed to reflect differences in the behavioral effects of drugs (stimulating or sedative). According to the USPP data, the differences in the drug effects are accompanied not only by a different topography of changes in the USPP pattern, but also by an opposite direction of these changes. This fact makes it possible to suppose that, during pharmacological tests, the differential sensitivity of USPPs as an indicator of CNS sensitivity may be higher than that of the EEG, in view of the closer relationship between the behavioral and electrographic changes.
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