Abstract
In 6 human subjects caerulein, a decapeptide isolated from frog skins, slightly stimulated gastric acid secretion when given alone. This peptide, added in a dose of 0.1µg/kg/hr to intravenous infusion of pentagastrin in a dose of 2.0µg/kg/hr, produced about 50% inhibition of near maximal gastric acid secretion. In 8 human subjects, however, it evidently increased gastric acid response to histamine diphosphate infused intravenously in a dose of 40 µg/kg/hr. The hypothesis of hormonal interaction was applied to explain the inhibitory and stimulatory effect of caerulein on pentagastrin and histamine-induced gastric acid secretion in man.
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