Abstract
We aimed to explore the clinical efficacy of breast-conserving surgery and modified radical mastectomy on the quality of life (QoL) in patients with early breast cancer. A total of 100 patients treated with breast-conserving surgery (BCS) were recruited in the BCS group, and 100 patients treated with modified radical mastectomy (MRM) in the MRM group. Our results showed that patients had significantly shorter operation time and hospital stay, smaller incisions, and less intraoperative blood loss in the BCS group than in the MRM group. The total complication rate was significantly lower in the BCS. The rate of good-to-excellent aesthetic outcomes in the BCS group was significantly. At one year and three years after surgery, the QoL in the BCS group was significantly higher than that in the MRM group (P<0.0001). In conclusion, BCS is as effective as MRM in early breast cancer, but confers better perioperative and aesthetic outcomes, higher QoL, and lower postoperative complication rate.
Highlights
Breast cancer (BC) is the most common malignancy and one of the leading causes of cancer death among women worldwide (Mavaddat et al, 2019)
In the breast-conserving surgery (BCS) group, 6 of 136 patients dropped out one year after surgery and 30 of 136 patients dropped out three years after surgery, only 100 patients were enrolled
3.3 Comparison of complication rates. Patients in both groups presented with subcutaneous effusion, subcutaneous hemorrhage, infection, and upper limb edema, and no skin flap necrosis was found in the BCS group while one flap necrosis was found in the modified radical mastectomy (MRM) group
Summary
Breast cancer (BC) is the most common malignancy and one of the leading causes of cancer death among women worldwide (Mavaddat et al, 2019). Potential risk factors for BC include high body mass index, older age, family history, long menstrual periods, use of oral contraceptives, and exposure to radiation (Lee et al, 2019; Morra et al, 2019; Ein Ali Afjeh et al, 2020; Hossen et al, 2021). The vast majority of breast tumors are originated from glandular epithelial cells. Invasive ductal carcinoma is the most common type of BC (approximately 70%), followed by lobular, medullary, mucinous, comedo, papillary, tubular, and inflammatory carcinomas (DeSantis et al, 2017; von Minckwitz et al, 2017). The incidence of breast cancer in China accounts for about 10% of all female malignant tumors (Deng et al, 2019). With the development of imaging diagnosis, puncture technology and women’s health awareness, the early detection rate of BC has been greatly improved (Cardoso et al, 2019; Thakur et al, 2019)
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