Effect of bone marrow, spleen, and peritoneal exudate cells on metastasis of tumor cells in the lungs of Syrian hamsters

Abstract

Nonactivated cells of the bone marrow (BM), spleen (SC) and peritoneal exudate (PE) of normal randombred Syrian hamsters are capable to inhibit (when administered to the blood channel) spontaneous metastases and colony-formation of tumor cells in the lungs of Syrian hamsters. The inhibitory effect was recorded after administering cells of the normal BM and PE but not of SC. The inhibitory effect on pulmonary metastases was in good agreement with the dose of effector cells. Inhibition of pulmonary metastases was effected by a single administration of BM and PE cells 5-8 days before inoculation of tumor cells, in conjunction with these cells and even within the first 5 days after administering tumor cells to the blood flow. In 50-60% of the animals, pulmonary metastases were completely suppressed; in the remainder of the animals, the rate of metastases was either decreased or the pattern of pulmonary metastases occurrence was similar to that seen in the control.