Effect of bombesin on release of gastrin, CCK, secretin and pancreatic exocrine secretion

Abstract

EFFECT OF BOMBESIN ON RELEASE OF GASTRIN, CCK, SECRETIN AND PANCREATIC EXOCRINE SECRETION. M Miyata, S Guzma, PL Rayford, JC Thompson. Department of Surgery, The University of Texas Medical Branch, Galveston, Texas. Bombesin has been show to stimulate pancreatic output of protein and to release gastrin and CCK. The present study was undertaken to determine whether the efiects of bombesin could be related to the dose of the peptide administered and whether bombesin released secretin. Methods Four doses of bombesin (0.125, 0.25, 1.0 and 2.0 ug/kg-hr, for 60 min) were infused into 4 conscious dogs with chronic pancreatic and gastric fistulas, which were kept opened during the study. Peripheral blood for measurement of gastrin, CCK and secretin (pg/ml) and pancreatic juice for volume (ml/15 mi), HC03(uEq/15 min) and protein (mg/15 min) were collected at regular intervals. Results -. Bombesin (vg/kg-hr) Basal 0.125 0.25 1.0 2.0 Pancreatic juice VOlUme 1+0.3 2.7i0.2 2.4kO.4 2.7i0.5 5.611.4 HC0320f7 80?8 7Or12 88i23 210%55 Protein 19i6 88i-11 79110 89-cl3 171+39 Peripheral blood Gastrin 5526 228+35 223129 271i31 531?72 CCK (plasma) 80?1