Abstract
Postural changes of functional residual capacity (FRC) and pulmonary N2 clearance efficiency were studied in six male subjects placed supine on a tilting table, in head-up, horizontal and head-down positions. FRC varied linearly with the angle of tilt. The lung clearance index (LCI) increased significantly in the supine and head-down positions, compared to the head-up positions, which indicates less uniform gas distribution in the former postures. This was confirmed by analysis of semilogarithmic graphs of N2 washout. Inhalation of epinephrine did not affect the postural changes of FRC and LCI, but caused a small increase of LCI irrespective of posture. The increased uneven distribution in head-down and supine positions is probably a consequence of the lung volume decrease in these postures, and may be explained by mechanical factors such as surface tension, which tend to close lung units when the lungs are deflated. Bronchomotor tone has no appreciable influence on these postural changes in normal subjects. Submitted on July 13, 1961
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