Abstract
Purpose Centrifugal LVADS are set at fixed pump speed with output sensitive to loading conditions. At fixed speeds, exercise increases pump flow mainly due to increased venous return. Suction events may occur in the setting of decreased venous return. We examined whether passive filling affected pump output or predisposition to suction. Methods and Materials Nine patients (55.3±11yrs; pump speed 2655±88rpm) implanted with the HeartWare HVAD were studied at 30° passive head-up tilt for 2mins and then performed ankle flexion exercise for a further 2mins. This regimen was repeated at 60° and 80° passive head up tilt. Patients were then returned to horizontal. Seven of nine patients were then studied at 20° passive head-down tilt. Baseline pump flows, MAP, HR, echo were recorded at each time point. Data was analysed using repeated measures ANOVA with post-hoc Bonferroni correction. Results Aortic valve remained closed in 8 patients, was intermittently open in one and did not change during study. LVAD flow decreased significantly from baseline (4.9±0.6 L/min) with passive head-up (30° 4.4±0.6; 60° 4.4±0.5; 80° 4.4±0.5L/min), p Conclusions Centrifugal LVAD flows are affected by body position. Flows return to normal with only minor active exercise. [ figure 1 ]
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
