Effect of body mass index on PSA in northeast Mexican patients

Abstract

ObjectiveTo evaluate the effect of body mass index (BMI) on PSA in northeast Mexican patients included in prostate cancer (PCa) early detection screening campaigns offered by our institution. Materials and methodsOne hundred and ninety seven patients came voluntarily to our PCa early detection screening campaigns. Exclusion criteria: PSA >10ng/dl, patients on 5-α reductase inhibitors or hormonal replacement. Overweight and obesity were considered when BMI was between 25–29.9 and ≥ 30kg/m2 respectively. Simple linear and multiple regressions were used in the statistical analysis. Mean and standard deviation were utilized to evaluate spread and normal distribution. p Values <0.05 were considered statistically significant. ResultsOne hundred and fifty-two patients were included in this study. Forty-four percent (83) and 30.3% (46) presented with overweight and obesity, respectively. Mean BMI was 28.16kg/m2 (SD 1.77). A statistically significant negative effect of BMI on PSA was observed in the linear regression. This effect persisted when adjusted for age in the multiple regression model. A decrease of 0.085ng/dl for every unit of BMI (p<0.001) was observed in the simple linear regression. This value was 0.07 in the multiple regression (p=0.006). ConclusionsA higher negative effect of BMI on PSA was found in comparison to published literature. A higher proportion of patients with BMI>25kg/m2 than the national mean was observed. A multicentric national study is needed in order to challenge these results.