Abstract
Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects of Bone morphogenetic protein-2 (BMP-2) soaked sutures for cartilage repair, using a rat model of xyphoid healing. Vicryl-resorbable sutures were presoaked in BMP-2 solutions prior to animal experimentation. Rat xyphoid process (an avascular hyaline cartilage structure) was surgically ruptured followed by repair procedures with regular suture or with sutures that were pre-soaked in BMP-2 solutions. In vitro assessment indicated that presoaking the Vicryl-resorbable sutures with 10 µg/mL BMP-2 resulted in a sustained amount of the growth factor release up to 7 days. Histological analysis suggested that application of this BMP-2 soaked suture on the rat xyphoid process model significantly improved the avascular cartilage healing compared to non-soaked control sutures. In conclusion, data here confirm that the rat xyphoid process repair is a reproducible and inexpensive animal model for meniscus and other cartilage repair. More importantly, coating of BMP-2 on sutures appears a potential avenue to improve cartilage repair and regeneration. Further study is warranted to explore the molecular mechanisms of this strategy.
Highlights
Arthroscopy of the knee for meniscal pathology is a very common orthopedic procedure performed in the United States
Concentration coated vitro Bone morphogenetic protein-2 (BMP-2) more BMP-2Inonto the suture an amount of the factor and was released to the more BMP-2 onto the suture that sustained an amount of the growth factor and was released to eluting the solution up to 21 days (Figure 2)
The sutures soaked in a low dose of BMP-2 quickly all growth factor in thefactor early days, while the sutures with μg/mLBMP-2
Summary
Arthroscopy of the knee for meniscal pathology is a very common orthopedic procedure performed in the United States. Since the early stages of knee arthroscopy, meniscectomy remains the dominant treatment for meniscal tears. With removal of a part of the meniscus, the total contact area between the femur and tibia is decreased and the smaller area of tibiofemoral contact bears much higher pressures [3]. This can alter the knee mechanics and lead to earlier onset of osteoarthritis. The mounting evidence of negative long-term results following meniscectomy has led to increasing research in meniscal repair. Tears over 4mm from the periphery of the meniscus are unlikely to heal with repair [8]
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