Abstract
BackgroundThis study aims to analyze the effect of the body mass index (BMI) on E2, P and LH values in females who received intrauterine insemination (IUI) treatment on human chorionic gonadotropin (HCG) day.MethodsA total of 2319 cycles of IUI-assisted pregnancy treatment were selected in our hospital. Based on the BMI, female infertility patients are divided into three groups: normal weight group, overweight and obese group.ResultsFor patients with natural cycles and ≤ 35 years old, there were 440, 178 and 197 cases in the three groups, respectively. For patients with natural cycles and > 35 years old, there were 90, 83 and 81 cycles in the three groups, respectively. For patients with induced ovulation cycle and ≤ 35 years old, there were 425, 203 and 516 cases in the three groups, respectively. For patients with induced ovulation cycle and > 35 years old, there were 26, 26 and 54 cases in the three groups, respectively.ConclusionWhen a patient is ≤35 years old, the BMI affects the E2, LH and P values on the day of artificial insemination. However, the BMI is negatively correlated with E2, LH and P in IUI on HCG day. After controlling for age and assisted pregnancy, the correlation analysis revealed that the BMI is negatively correlated with hormone E2 and LH. The higher the BMI was, the lower the levels of hormones E2, LH and P became. However, in the present study, the BMI did not significantly improve the clinical pregnancy rate of patients who received IUI.
Highlights
This study aims to analyze the effect of the body mass index (BMI) on E2, P and luteotropic hormone (LH) values in females who received intrauterine insemination (IUI) treatment on human chorionic gonadotropin (HCG) day
According to the World Health Organization (WHO) reference standard for Asian women’s BMI, the above four groups were further divided into three subgroups: normal weight group (18.5 kg/m2 ≤ BMI ≤ 23.0 kg/m2), overweight group (23 kg/m2 ≤ BMI < 25 kg/m2), and obese group (25 kg/m2 ≤ BMI ≤ 35.1 kg/m2)
The findings revealed that BMI is negatively correlated with the levels of hormone E2, LH and P on HCG day
Summary
This study aims to analyze the effect of the body mass index (BMI) on E2, P and LH values in females who received intrauterine insemination (IUI) treatment on human chorionic gonadotropin (HCG) day. With the rapid development of the economy, the pace of people’s life speeds up, material living standard improves, and obesity becomes a global public health problem. It has been proven by growing evidence that obesity can result in infertility, such as menstrual cycle disorder, reduced fertility, abnormal ovulation, high androgen levels and insulin resistance [1,2,3,4,5]. The study conducted by Souter et al [16] revealed that the decrease in serum estradiol and LH levels in obese people may be correlated to the increase in concentration of antigonadal hormone, which is similar to the leptin in serum
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