Abstract
Objective: To evaluate hepatoprotective effects of ethanol extract of aerial part of Blumea lacera (BLEE) against ethanol-induced hepatotoxicity in rats.
 Methods: The in vivo antioxidant activity of BLEE was assessed by determining the tissue glutathione (GSH) and lipid peroxidation (LPO) levels. The BLEE at the doses of 200 and 400 mg/kg and silymarin 100 mg/kg administered to the ethanol challenged rats. The effects of BLEE and silymarin on Physical and Biochemical Parameters were measured. Similarly, histopathological changes of the liver were studied.
 Results: The BLEE showed in vivo antioxidant activity. A significant (P<0.001) decrease in SGOT, SGPT, ALP, total and direct bilirubin was observed in BLEE treated group at doses i.e. 200 mg/kg and 400 mg/kg as compared to intoxicated group. Liver damage in animal pretreated with BLEE was minimal with distinct preservation of structures and the architectural frame of the hepatic cells.
 Conclusion: These findings demonstrated the hepatoprotective effects of BLEE against ethanol-induced liver damage.
Highlights
Liver is the first and major organ to metabolize all foreign compounds, and it is susceptible to many different diseases [1]
Jaundice and hepatitis are two major disorders of liver that increase the risk for mortality
Our literature survey revealed that the hepatoprotective activity of Blumea lacera (BLEE) was not investigated; these activities have been investigated in the present study
Summary
Liver is the first and major organ to metabolize all foreign compounds, and it is susceptible to many different diseases [1]. Chronic alcohol intake produces a variety of physiological changes and damages to the liver [2]. At least 80 % of heavy drinkers were reported to develop steatosis, 10-35% alcoholic hepatitis, and approximately 10 % liver cirrhosis [3]. Jaundice and hepatitis are two major disorders of liver that increase the risk for mortality. Treatment options for hepatotoxicity are very limited [4]. There has been a great deal of interest for the role of complementary and alternative medicines in the treatment of various acute and chronic diseases. Natural products have made a significant contribution for the treatment of hepatotoxicity. Our literature survey revealed that the hepatoprotective activity of BLEE was not investigated; these activities have been investigated in the present study
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