Abstract
Objective To analyze the effect of blood glucose control level on coronary artery lesions in patients with coronary heart disease complicated with diabetes. Methods One hundred patients with coronary heart disease complicated with type 2 diabetes mellitus treated at our hospital from March, 2013 to February, 2015 were selected as study objects and were divided into an observation group and a control group according to different blood glucose control levels (plasma glycosylated hemoglobin < 6.5% and fasting blood glucose ≤ 7.0 mmol/L indicate ideal blood glucose control), 50 cases for each group. The degree of coronary artery stenosis, the number of affected vessels, and the number of cases with diffuse lesions were compared between these two groups. The Gensini scores of coronary artery disease in the two groups were analyzed. The levels of von Willebrand factor (vWF) were compared between these two groups by enzyme linked immunosorbent assay (ELISA). Results There were no statistical differences in the degrees of coronary artery stenosis between the observation group (non-severe 46.00%, severe 34.00%) and the control group (non-severe 36.00%, severe 44.00%) (P>0.05). The numbers of affected vessels (single 4.00%, double vessels 60.00%, three vessels 36.00%) and diffuse lesions (16.00%) in the observation group were significantly lower than those in the control group (single 2.00%, double vessels 24.00%, three vessels 74.00%, diffuse lesions 42.00%) (P<0.05); HbA1c [(2.17±1.20)%], Gensini score [(49.27±1.14)] and vWF [(65.23±1.24)%] in the observation group were significantly lower than those in control group (P<0.05). Conclusion Diabetes aggravates the degree of coronary artery lesions. Therefore, coronary artery lesions can be reduced by controlling blood glucose levels and reducing vWF. Key words: Blood glucose; Control; Coronary heart disease; Diabetes; Coronary artery lesions; Effect; Analysis
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