Abstract
Maturation of oocyte is start at embryonic stage, it is hesitate during prophase I of meiosis, start to develop in puberty with developing follicles. During the development stages of oocyte at meiosis I and meiosis II, many molecular mechanisms controls. The most important research topic is investigated to detection of meiotic arrest in infertile patients who suffering oocyte arrest because of failure of meiotic checkpoints. A chemical substance, Bisphenol A, used several materials such as polycarbonate plastic and epoxy resins, baby and water bottles, plastic cups, reusable food containers, food packaging and several materials such as frequently used in daily life.
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