Effect of bioglass on in vitro bioactivity and cytocompatibility of biphasic α-tricalcium phosphate/gypsum cements

Abstract

ABSTRACT In the present study, a novel bioglass (BG)-incorporated α-triphosphate calcium (α-TCP)/gypsum composite cement with poly (γ-glutamic acid) (PGA) aqueous solution as a reactive liquid phase was developed. The effects of BG content on the properties of the PGA modified α-TCP/gypsum composite cement (PGA-Cement) were systematically investigated. Results revealed that the introduction of BG (5–20 wt%) maintained the injectibility and anti-washout ability, but prolonged the setting time to reasonable initial setting time of ~13-24 min and final setting time within ~24-33 min. Moreover, after the dosage of 5 wt% BG, the compressive strength increased from 21.52 ± 1.68 MPa of PGA-Cement to 30.17 ± 1.00 MPa of 5BG-PGA-Cement. Meanwhile, in vitro test indicated that the prepared 5BG-PGA-Cement and 10BG-PGA-Cement had better degradation and bioactivity than 20BG-PGA-Cement. All these results suggest that BG-incorporated α-TCP/gypsum composite cement have broad application prospects in minimally invasive surgery for the treatment of bone defects.