Abstract
The aim of this study was to investigate the effect of dopa and catecholamines on the generation of oxygen active species during oxidation of farmorubicin by "Fenton-like" reagents using chemiluminescent and spectrophotometric techniques. The tested catechols were found to reduce the light emission accompanying oxidation of farmorubicin by Co(II) + H2O2 and Cu(II) + H2O2 mixtures. The quenching effect was followed by their rapid oxidation to aminochromes possessing toxic activities.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have