Abstract
Amoxicillin, which inspite of being effective is losing its importance due to less bioavailability. Bioavailability could be enhanced by combining the antibiotics with bioenhancers like Piperine and Ginger resin. The present abstract deals with the use of piperine and ginger resin in increasing the bioavailability of amoxicillin using the insitu SPIP method. Piperine, isolated was found to be 99 % pure and ginger resin contained 4.36 % w/w of gingerol. The absorption of amoxicillin increased with addition of Piperine (1.2, 1.5, 1.8 % w/w of amoxicillin) in a dose dependant manner reaching saturation after 45 minutes wheras Ginger resin (6, 7, 8 % w/w of amoxicillin) failed to show this effect in the invitro studies. Piperine enhanced the permeation of Amoxicillin but ginger resin failed to show this effect using the insitu SPIP method. The method used may be appropriate for bioenhancers acting on transporters, metabolizing enzymes or modulators of diffusivity but not for those acting on gut motility. The combination of Piperine and Amoxicillin trihydarte may have a potential in reducing the dose, shortening the treatment period thus reducing drug-resistance problems of the antibiotic.
Highlights
Three major factors namely solubility, dissolution, and intestinal permeability, affecting oral drug absorption can be estimated using the biopharmaceutics classification system (BCS)
Piperine concentrations of 1.5 and 1.8 % w/w significantly enhanced the diffusion of Amoxicillin trihydrate at 15, 45 and 60 min (p< 0.0001)
1.5 and 1.8 % w/w of Piperine additions did not show a significant difference in the diffusion of Amoxicillin trihydrate when compared with each other
Summary
Three major factors namely solubility, dissolution, and intestinal permeability, affecting oral drug absorption can be estimated using the biopharmaceutics classification system (BCS). Piperine and Ginger resin are known to be the constituents of trikatu, an Ayurvedic formulation, indicating three drugs which enhance the bioavailability [7]. Varying concentrations of Piperine (1.2, 1.5 and 1.8 % w/w) [9] and Ginger resin (6, 7 and 8 % w/w) [9,10] were added to different reservoirs to check the enhancement in diffusion across the synthetic semi permeable membrane.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
