Abstract
Breast cancer is the most frequently diagnosed cancer and the leading cause of death among females. Ganoderma spp has been used to treat different diseases including inflammation and cancer. This study aimed to compare the anti-proliferative potential and bioactive components of Ganoderma spp sourced from two different hosts. Ethanol extract of two Ganoderma spp isolated from a dead trunk of Mangifera indica tree and dead stump of Persea americana in Oshodi and Yaba area of Lagos State, Nigeria respectively, were used for this study. Cytotoxic activity against human breast (MCF-7) adenocarcinoma cell line was evaluated via the 3–(−4–5-dimethythiazol–2-yl)-2-5-diphenyl tetrazolium bromide (MTT) assay and the extracts were also subjected to GC – MS chromatographic analysis. These extracts elicited dose dependent cytotoxicity on MCF-7 cell line after 48 hours treatment, extract from Ganoderma spp obtained from Yaba and Oshodi had IC50 values of 3.092μg/ml and 5.465μg/ml respectively. The GC- MS chromatographic analysis of the ethanol extract of Ganoderma spp isolated from the dead mango tree, showed 32 peaks which indicate the presence of 32 bioactive components, the most prevailing components were methyl – dihydroisosteviol (15.315%), methyl stearate (7.8%) and trans – 13 –octadecenoic acid methyl ester (7.25%). Whereas only two compounds were identified from Ganoderma spp isolated from the dead stump of Persea americana, the more prevalent is 2-t –butyl- 5- chloromethyl -4- oxoimidazoline -1- carboxylic acid t- butyl ester (99.446%). The findings of this study indicate that there is some justification for the use of Ganoderma spp as traditional anticancer medicinal herbs. GC-MS Profile of Ganodema spp Isolated from Mangifera indica GC-MS Profile of Ganodema spp Isolated from Persea americana GC-MS Profile of Ganodema spp Isolated from Mangifera indica GC-MS Profile of Ganodema spp Isolated from Persea americana This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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