Abstract
The interrelationship between the biliary secretion of phospholipids, bilirubin and bile acids was studied in New Zealand rabbits after acinar zone 3 hepatocyte damage induced by bromobenzene (4 mmol/kg body wt; i.p.). Treatment with the toxin did not significantly modify biliary phospholipid secretion, suggesting that the transport of phospholipids is mainly a zone 1 function. Bilirubin infusion at 1 mumol/min kg body wt induced a significant inhibition in biliary phospholipid secretion both in control and treated animals. This effect was overcome by the additional infusion of sodium glycodeoxycholate at 1.6 mumol/min kg body wt, although higher increases in phospholipid output were found in the control than in the treated rabbits. This would be related to the lowered recruitment of zone 3 cells for secretion in bromobenzene-damaged livers.
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