Abstract
The membrane potential of rabbit nasal mucosa was measured in vitro to investigate the electrical properties of the tissue. The influence of bile salts, that are enhancers for nasal absorption of peptide drugs, on the nasal mucosa was also studied from the viewpoint of membrane potential. The nasal mucosa membrane was negatively charged. The membrane charge density (θ∗) was − 3.4 mmol 1 in KCl solution and − 3.5 mol 1 in NaCl solution. These membrane potentials of the nasal membrane for isotonic solution were not changed by pretreatment with 1% ( w v ) bile salts (sodium glycocholate and dehydrocholate). The membrane potential of nasal mucosa for NaCl and KCl deviated from the simple Donnan equilibrium theorem in the region of low bulk concentration, whereas the membrane potential of the cellulose membrane obeyed the theorem over all the bulk solution concentrations. This difference may be a result of the variation in the amount o ions adsorbed on the nasal mucosa membrane.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
