Abstract

THIS PAPER is a preliminary report of studies still in progress on the reduction of gastric acidity in the dog by the use of radioactive phosphorus, known as P 32 . The basic purpose is to determine whether beta irradiation from P 32 might be effectively and safely used in the treatment of peptic ulcer by reducing gastric secretion. Several workers 1 have produced a decrease in acidity for varying intervals with the use of gamma rays. Palmer and Templeton 2 in 1934 reported 100 cases of peptic ulcer treated with roentgen rays in which they irradiated the stomach anteriorly and posteriorly over a period of ten to twelve days. They reported a definite decrease in gastric acidity, which varied in extent and duration. In 1942 two New Zealand investigators, Jenkins and McGeorge, 3 using gamma rays, placed radium needles in a rubber-covered tube and passed it into the stomach under

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