Abstract
Objective To investigate the effect of berberine on the blood concentration of cyclosporine A (CsA) in the renal transplant recipients. Methods Fifty cardaveric renal transplant recipients were randomly divided into 2 groups: 30 patients receiving berberine in comparison with other 20 non berberine-receiving patients. The dosage of berberine was 0.2g each time, 3 times per day. The blood concentration of CsA was assayed before the patients took berberine. After 7 days of their taking berberine, the blood concentration of CsA, renal and liver function were assayed on the condition that the dosage of CsA was kept constant and no other medicines affecting the concentration of CsA were taken.Results The concentrations of CsA in the 30 berberine-receiving patients were apparently increased in comparison with those non berberine-receiving ones (P＜0.001). Conclusion The usage of berberine in association with CsA could increase the concentration of blood CsA and reduce the dosage of CsA.
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