Abstract
The effects of 5 benzodiazepines on basal and K+-induced Ca2+ concentration in synaptoneurosomes from intact and stressed C57B1/6 and BALB/c mice were studiedin vitro. Membrane depolarization induced by low KCl concentrations produced different effects on Ca2+ accumulation by synaptoneurosomes from two mouse strains. Benzodiazepines appliedin vitro exerted no effects on Ca2+ influx. In synaptoneurosomes from both C57B1/6 and BALB/c mice exposed to emotional stress diazepam in a dose of 5 mg/kg reduced the basal and K+-induced Ca2+ accumulation.
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