Abstract
Thiabendazole (100 μ M) and fenbendazole (250 μ M) were found to inhibit U- 14 C-glucose, (Na)-1- 14C-palmitate and (Na)-1- 14C-acetate uptake markedly ( P<0.001) in adult Trichuris globulosa. The inhibition was more pronounced with thiabendazole than with fenbendazole. 14C-Glucose was found to be Na +-dependent and a mediated process. Bile salts, viz. sodium cholate and sodium desoxycholate in the concentration range of 5–10 m M, were found to inhibit the uptake of 14C-glucose and 14C-palmitate ( P<0.01) by the parasites. The optimum pH for (Na)-1- 14C-palmitate and (Na)-1- 14C-acetate uptake was 6.7 and 6.2, respectively while the optimum temperature for the uptake of these compounds was 37°C.
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