Abstract
Bee venom has been used to treat and reduce chronic inflammatory diseases such as Rheumatoid arthritis, It has anti-inflammatory, anti-nociceptive and anticancer effects. The aim of the current study was to investigate effects of bee venom on gene expression of HSP70 and IL-1β in male albino rats with arthritis and compare it with prednisolone drug. The current study includes two experiments, the first experiment continued for 14 days and the second for 28 days.(84) mature male albino rats (135–150) gm, (42) male rats for each experiment divided in to (7) groups, (6) animals for each group and included: the first group (negative control) was injected by (0.1ml/animal) from physiological normal saline (0.9% Nacl), the second group (Arthritis group) was injected by (0.1ml/animal) formaldehyde, the third group (normal group) was injected by bee venom (i.p) (1mg/kg of B.W), the fourth group (normal group) was treated orally with prednisolone (5mg/kg of B.W), the fifth group (Arthritis group) was injected by bee venom (i.p) (1mg/kg of B.W), the sixth group (Arthritis group) was treated orally by prednisolone (5mg/kg of B.W) and seventh group (Arthritis group) was injected by bee venom (1mg/kg of B.W) and treated orally with prednisolone (5mg/kg of B.W). Our results demonstrated that G2 group showed a significant increase (P≤0.05) in gene expression of HSP70 and IL-1β compared with control and other groups during the first and second period of experiment. The G3 and G4 groups showed a significant decrease (P≤0.05) in gene expression of HSP70 and IL-1β compared with G2 group through the two periods, while the G5, G6 and G7 groups showed a significant decrease (P≤0.05) in gene expression of HSP70 and IL-1β compared with G2 group. Finally the G7 group showed a significant increase (P≤0.05) in gene expression of HSP70 and IL-1β compared with G5 group through the two periods of experiment. We conclude from the present study that bee venom attenuates development of arthritis by decreasing gene expression of HSP70 and IL-1β and the use of bee venom is safer than prednisolone due to prednisolone has adverse effects especially in high dose.
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