Abstract
胆管癌对放疗、化疗不敏感,手术效果差,如何提高其治疗效果,一直是困扰临床医师的难题[1].作者既往的实验[2,3]显示胆管癌组织中Bcl-2高表达,胆管癌细胞株QBC939中Bcl-2阳性表达,Bcl-2反义寡核苷酸(ASODN)可抑制QBC939细胞增殖.本研究将Bcl-2 ASODN作用于人胆管癌细胞株QBC939,旨在探索Bcl-2 ASODN作用的分子机制,为胆管癌反义基因治疗提供实验依据。
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