Effect of Baseline Characteristics and Tumor Burden on Vaspin Expression and Progressive Disease in Operable Colorectal Cancer.

Jung-Yu Kan,Yu-Da Lin,Sin-Hua Moi,Yi-Chen Lee,Wan-Yi Ho

doi:10.3390/diagnostics10100801

Abstract

Colorectal cancer is a highly heterogeneous malignancy in the Asian population, and it is considered an important prognostic factor for baseline characteristics, tumor burden, and tumor markers. This study investigated the effect of baseline characteristics and tumor burden on tumor marker expression and progressive disease in colorectal cancer by using partial least squares variance-based path modeling (PLS-PM). PLS-PM can be used to evaluate the complex relationship between prognostic variables and progressive disease status with a small sample of measurements and structural models. A total of 89 tissue samples of colorectal cancer were analyzed. Our results suggested that the expression of visceral adipose tissue-derived serpin (vaspin) is a potential indicator of colorectal cancer progression and may be affected by baseline characteristics such as age, sex, body mass index, and diabetes mellitus. Moreover, according to the characteristics of tumor burden, the expression of vaspin was generally higher in each progressive disease patient. The overall findings suggest that vaspin is a potential indicator of the progressive disease and may be affected by the baseline characteristics of patients.

Highlights

Colorectal cancer is a highly heterogeneous malignant disease with a high prevalence in the Asian population; in addition to causing a poor quality of life, it accounts for high cancer-related morbidity and mortality due to its poor prognosis, especially in those with disease progressed lesions [1,2,3,4,5].Studies have classified the prominent clinicopathological factors into multiple categories based on their features [6,7]
The results demonstrated that patients with progressive disease with different tumor burden characteristics generally had higher vaspin expression
The study results demonstrated that vaspin expression is a potential indicator of colorectal cancer progression status and might be affected by baseline characteristics including age, sex, body mass index (BMI), and diabetes mellitus (DM)

Summary

Introduction

Colorectal cancer is a highly heterogeneous malignant disease with a high prevalence in the Asian population; in addition to causing a poor quality of life, it accounts for high cancer-related morbidity and mortality due to its poor prognosis, especially in those with disease progressed lesions [1,2,3,4,5].Studies have classified the prominent clinicopathological factors into multiple categories based on their features [6,7]. Colorectal cancer is a highly heterogeneous malignant disease with a high prevalence in the Asian population; in addition to causing a poor quality of life, it accounts for high cancer-related morbidity and mortality due to its poor prognosis, especially in those with disease progressed lesions [1,2,3,4,5]. Clinicopathological factors including the baseline characteristics, tumor burden, and tumor markers, which can be affected or associated with short- and long-term survival outcomes in colorectal cancer, are considered to be prognostic factors [8,9,10]. Baseline characteristics of patients with cancer include the age at which cancer was diagnosed, sex, and comorbidity status. Factors that are directly measured from the tumor lesion are considered tumor burden factors. In addition to indicating the molecular expression from cancer cells in the tumor, tumor markers play a definite

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Results

Discussion

Conclusion