Abstract
High-fat diet (HFD) is associated with impairment of insulin sensitivity. We investigated the effects of Bangle (Zingiber purpureum) extract (Ba) with exercise training (Ex) on phosphorylation of Akt and mammalian target of rapamycin (mTOR), and autophagy flux in the gastrocnemius (GM) of HFD-fed rats. The rats, on a diet providing 45% of energy from fat, were divided into four groups: untreated (HFD), 1.5% Ba-treated (HFD + Ba), 1.5% Ba with Ex-treated (HFD + Ba + Ex), and Ex-treated (HFD + Ex) groups. The controls were fed a normal diet. The homeostatic model assessment of insulin resistance index and non-esterified fatty acid levels were decreased in the HFD + Ba + Ex. The HFD + Ba + Ex showed decreased phosphorylated Akt and mTOR levels, and increased levels of autophagy flux markers, LC3B-II and Beclin 1, compared to the HFD. In conclusion, the combination of Ba and Ex modulates Akt/mTOR phosphorylation and the autophagy flux in the GM and may attenuate insulin resistance induced by a HFD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
