Abstract
Abstract Objective: To investigate the effect of Bacailin on inflammatory mediator levels and microcirculation disturbance in severe acute pancreatitis (SAP) rats and explore its therapeutic mechanism on this disease. Methods: SAP model rats were randomly divided into model control group and Baicalin treated group, 45 rats in each group. The same number of normal rats were included in sham-operated group. These groups were further subdivided into 3 h, 6 h and 12 h subgroups, respectively (15 rats in each subgroup). At 3, 6 and 12 hours after operation, rats were killed to conduct the following experiments: (1) to examine the mortality rates of rats, the ascites volume and pancreatic pathological changes in each group; (2) to determine the contents of amylase, PLA~2~, TXB~2~, PGE~2~, PAF and IL-1[beta]; in blood as well as the changes in blood viscosity. Results: (1) Compared to model control group, treatment with Baicalin is able to improve the pathological damage of the pancreas, lower the contents of amylase and multiple inflammatory mediators in blood, decrease the amount of ascitic fluid and reduce the mortality rates of SAP rats; (2) at 3 hours after operation, the low-shear whole blood viscosity in Baicalin treated group was significantly lower than that in model control group;at 12 hours after operation, both the high-shear and low-shear whole blood viscosity in Baicalin treated group were also significantly lower than those in model control group. Conclusion: Baicalin, as a new drug, has good prospects in the treatment of SAP since it can exert therapeutic effects on this disease through inhibiting the production of inflammatory mediators, lowering blood viscosity, improving microcirculation and mitigating the pathological damage of the pancreas.
Highlights
In recent years, the roles of microcirculation disturbance in the pathogenesis of severe acute pancreatitis (SAP) have attracted extensive attention [1,2]
We investigate the effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in SAP rats and explore its therapeutic mechanism, thereby providing a theoretical basis for treating this disease with Baicalin
We found that, at all time points after operation in model control group and at 6 and 12 hours after operation in Baicalin treated group, the contents of PAF were significantly higher than those in sham-operated group (P
Summary
The roles of microcirculation disturbance in the pathogenesis of severe acute pancreatitis (SAP) have attracted extensive attention [1,2]. Microcirculation disturbance refers to the morphological alterations and functional disturbance of blood vessels or blood flow at microcirculatory level. Hemorheological changes are one of the most important factors that can induce microcirculation disturbance. Even in the early stage of SAP, an obvious disturbance of pancreatic microcirculation is present. It has important significance to improve pancreatic microcirculation in the treatment of SAP [3]. We investigate the effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in SAP rats and explore its therapeutic mechanism, thereby providing a theoretical basis for treating this disease with Baicalin
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