Abstract
Uncontrolled glucose and lipid metabolism during diabetes, caused by a decrease in the synthesis of regulatory substances such as insulin and adiponectin, promotes the development of diabetic complications. One of the most frequent and devastating complications is diabetic nephropathy, which is characterized by high levels of proteinuria due to inadequate glomerular filtration. The aim of this study was to evaluate the effect of avocado oil on metabolic profile and the development of diabetic nephropathy in a model of type 2 diabetes.Goto‐Kakizaki rats were used as a model of type 2 diabetes, and avocado oil was administered orally for 3, 6 and 12 months. The results showed that treatment with avocado oil maintained for a longer time adiponectin levels, however had no effect on insulin levels. The treatment improved the lipid profile in rats by lowering cholesterol, triglyceride and LDL levels and maintaining HDL concentrations. Another important aspect was that avocado oil did not result in weight gain in diabetic rats. When evaluated renal function, the oil partially counteracted the increase in proteinuria observed in the diabetic group, while in the histopathological evaluation diabetic rats showed signs of diabetic nephropathy such as accumulation of extracellular matrix in the glomerulus and thickening of the basement membrane starting from 3 months of treatment. Treatment with avocado oil delayed the development of these alterations until 6 months.These results show that avocado oil improved several parameters of the metabolic profile and delayed the development of diabetic nephropathy, probably due to the components on avocado oil, since some of them have antioxidants functions, while others, such as oleic acid, have a beneficial effect on the metabolism of lipids and carbohydrates.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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