Abstract
Diabetes is characterized by an increase in ROS generation and impaired mitochondrial dysfunction in several tissues. Due to its high content of monounsaturated fatty acids (MUFA) and the presence of carotenoid antioxidants, we aimed to test if dietary avocado oil (AO) may attenuate ROS generation in association with a decrease in the peroxidizability index (PI) of membranes from liver and aortic mitochondria. In aortic mitochondria from diabetic rats, 90‐days administration of avocado oil induced both an 8% increment in MUFA content and a 20.6% decrease in PI when compared with the diabetic group. Moreover, a decrease of above 50% in ROS production was detected in mitochondria from the control and diabetic groups treated with AO. Regarding liver mitochondria, ROS production was 81% higher in diabetic mitochondria than in control. However, despite neither MUFA content nor PI was modified by AO treatment, the later decreased ROS generation in diabetic mitochondria at control levels. Together, these results suggest that avocado oil may decrease oxidative stress in different tissues by diverse mechanisms.
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