Abstract
Previous reports indicate that atropine enhances gastrin release stimulated by sham feeding or gastric distention in humans, suggesting that cholinergic mechanisms normally inhibit the gastrin responses to these stimuli. To investigate cholinergic regulation of gastrin release stimulated by dietary amino acids, we measured serum gastrin levels in healthy human beings before and after intragastric infusion of an amino acid meal and parenteral injection of one of four doses of atropine or saline. Following infusion of the meal, intragastric pH was held constant at 5.0 by in vivo intragastric titration, and gastric emptying was assessed by an indicator dilution method. Small intravenous doses of atropine (0.78 and 2.3 μg/kg) reduced amino acid mealstimulated gastrin release in every subject. For example, 2.3 μg/kg atropine reduced the average (±SE) gastrin response to the meal from 71 ± 15 to 53 ± 11 pglml in 10 subjects (p
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