Abstract
Gastric acid secretion—basal and stimulated by increasing doses of Pentagastrin or histamine—has been examined before and after administration of different doses of atropine in 20 duodenal ulcer patients with intact vagi and in 12 after surgical vagotomy. Atropine greatly depressed basal acid output and lowered the dose response curves to Pentagastrin and histamine, shifting them to the right. Significant inhibition of acid output was observed in basal secretion and at lower dose levels of gastric stimulation, whereas the maximal acid output remained unchanged both in patients with intact vagi and after surgical vagotomy.
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