Abstract
Gastrin release and HCl secretion was induced by electrical vagal stimulation in anesthetized cats. Both atropine (0.1-0.3 mg/kg) and methiamide (4-20 mg/kg) inhibited the HCl secretion (by approximately 60 and approximately 80 %). On the other hand, neither atropine (0.2-2 mg/kg) nor methiamide (20 mg/kg) inhibited the vagally induced gastrin release. Possible explanations of the atropine resistance of the vagal gastrin release mechanism are discussed.
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